| Subject ID | NMC065 |
| Sex | MALE |
| Dominant hand | LEFT |
| Test administered by | neuromedic@manusdevices.net |
| Test date and time | 2022-10-31 13:37 |
| Test battery | Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset |
| Operator comment | old patient tbl Madopar 1\2+1\4+1\4+1\2 |
Movement Disorder Evaluation
Important
This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.
Clinical Context
This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.
These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.
The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.
The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.
Subject and Recording Details
Overall Assessment
PD
Subject performance similar to PD population (recommend review of report details)
Clinical context
In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.
Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.
Symptom Scores
These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).
The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.
Micrographia
The micrographia symptom assessment is derived from a combination of factors in the elel task.
{'FN': 24, 'TN': 19, 'TP': 18, 'FP': 11}Tremor
The tremor score is a combination of features in the circle, spiral and both zizag tasks.
{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}Bradykinesia
The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.
{'FN': 41, 'TN': 29, 'TP': 1, 'FP': 1}Spatial Accuracy
The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.
{'FN': 12, 'TN': 9, 'TP': 30, 'FP': 21}Test Battery Details
Circle
| numCircles | 10 |
| timePerCircleMean | 18.3 |
| timePerCircleCoV | 0.336051 |
| timePerCircleSlope | -0.0883193 |
| meanError | 2.16381 |
| tremorFreq | 6.64062 |
| tremorRelPower | 29.6094 |
| tremorGyroAmpMean | 0.0457199 |
| tremorGyroAmpSlope | 0.00226941 |
| tremorGyroAmpCoV | 0.443635 |
| tremorCoordAmpMean | 0.0722201 |
| tremorCoordAmpSlope | 0.00213313 |
| tremorCoordAmpCoV | 0.46586 |
| tremorAccAmpMean | 0.0626467 |
| tremorAccAmpSlope | 0.00182368 |
| tremorAccAmpCoV | 0.468561 |
| tremorPcRelVar | 0.835378 |
| tremorPcX | -0.722199 |
| tremorPcY | 0.691685 |
Circle Segment 1
Duration 33.36 s, Accuracy Estimate 3.552 (lower is better)
Circle Segment 2
Duration 23.36 s, Accuracy Estimate 2.145 (lower is better)
Circle Segment 3
Duration 20.68 s, Accuracy Estimate 1.786 (lower is better)
Circle Segment 4
Duration 17.72 s, Accuracy Estimate 1.727 (lower is better)
Circle Segment 5
Duration 15.28 s, Accuracy Estimate 1.702 (lower is better)
Circle Segment 6
Duration 14.0 s, Accuracy Estimate 1.698 (lower is better)
Circle Segment 7
Duration 13.76 s, Accuracy Estimate 2.046 (lower is better)
Circle Segment 8
Duration 15.0 s, Accuracy Estimate 1.712 (lower is better)
Circle Segment 9
Duration 14.96 s, Accuracy Estimate 1.868 (lower is better)
Circle Segment 10
Duration 14.88 s, Accuracy Estimate 3.402 (lower is better)
Spiral
| numSpirals | 8 |
| timePerSpiralMean | 35.465 |
| timePerSpiralCoV | 0.289426 |
| timePerSpiralSlope | -0.0948353 |
| meanError | 2.51141 |
| tremorFreq | 6.73828 |
| tremorRelPower | 42.0717 |
| tremorGyroAmpMean | 0.0705067 |
| tremorGyroAmpSlope | 0.000530822 |
| tremorGyroAmpCoV | 0.487608 |
| tremorCoordAmpMean | 0.107009 |
| tremorCoordAmpSlope | 0.00156939 |
| tremorCoordAmpCoV | 0.462708 |
| tremorAccAmpMean | 0.086356 |
| tremorAccAmpSlope | 0.00052239 |
| tremorAccAmpCoV | 0.451706 |
| tremorPcRelVar | 0.793247 |
| tremorPcX | 0.897508 |
| tremorPcY | 0.440998 |
Spiral Segment 1
Duration 59.04 s, Accuracy Estimate 2.068 (lower is better)
Spiral Segment 2
Duration 38.8 s, Accuracy Estimate 2.562 (lower is better)
Spiral Segment 3
Duration 35.88 s, Accuracy Estimate 2.338 (lower is better)
Spiral Segment 4
Duration 32.52 s, Accuracy Estimate 2.9 (lower is better)
Spiral Segment 5
Duration 29.48 s, Accuracy Estimate 2.572 (lower is better)
Spiral Segment 6
Duration 31.8 s, Accuracy Estimate 2.614 (lower is better)
Spiral Segment 7
Duration 26.68 s, Accuracy Estimate 2.552 (lower is better)
Spiral Segment 8
Duration 29.52 s, Accuracy Estimate 2.486 (lower is better)
Elel
| eDurationMean | 0.813718 |
| eDurationStd | 0.217485 |
| eDurationStdnorm | 0.267273 |
| eDurationMedian | 0.745 |
| eDurationQuartdelta | 0.27 |
| eDurationQuartdeltanorm | 0.362416 |
| eDurationKurt | 3.56325 |
| eDurationTrenddiff | 0.05 |
| eDurationTrendratio | 1.06993 |
| eWidthMean | 3.339 |
| eWidthStd | 0.839781 |
| eWidthStdnorm | 0.251507 |
| eWidthMedian | 3.393 |
| eWidthQuartdelta | 1.02375 |
| eWidthQuartdeltanorm | 0.301724 |
| eWidthKurt | 4.77911 |
| eWidthTrenddiff | -0.234 |
| eWidthTrendratio | 0.931034 |
| eHeightMean | 7.185 |
| eHeightStd | 2.50459 |
| eHeightStdnorm | 0.348586 |
| eHeightMedian | 6.435 |
| eHeightQuartdelta | 2.5155 |
| eHeightQuartdeltanorm | 0.390909 |
| eHeightKurt | 3.19967 |
| eHeightTrenddiff | -0.351 |
| eHeightTrendratio | 0.946429 |
| eAspectMean | 0.489855 |
| eAspectStd | 0.126155 |
| eAspectStdnorm | 0.257536 |
| eAspectMedian | 0.469388 |
| eAspectQuartdelta | 0.197565 |
| eAspectQuartdeltanorm | 0.420899 |
| eAspectKurt | 2.56522 |
| eAspectTrenddiff | 0.0293904 |
| eAspectTrendratio | 1.06645 |
| eSlantMean | 0.00654564 |
| eSlantStd | 0.223726 |
| eSlantStdnorm | 34.1794 |
| eSlantMedian | -0.0153846 |
| eSlantQuartdelta | 0.225178 |
| eSlantQuartdeltanorm | -14.6366 |
| eSlantKurt | 4.39855 |
| eSlantTrenddiff | -0.0408163 |
| eRtopMean | 0.713266 |
| eRtopStd | 0.159096 |
| eRtopStdnorm | 0.223053 |
| eRtopMedian | 0.722222 |
| eRtopQuartdelta | 0.267355 |
| eRtopQuartdeltanorm | 0.370184 |
| eRtopKurt | 2.05549 |
| eRtopTrenddiff | -0.0316206 |
| eRbotMean | 0.720549 |
| eRbotStd | 0.357195 |
| eRbotStdnorm | 0.495727 |
| eRbotMedian | 0.705882 |
| eRbotQuartdelta | 0.484375 |
| eRbotQuartdeltanorm | 0.686198 |
| eRbotKurt | 2.96749 |
| eRbotTrenddiff | 0.191667 |
| eRrightMean | 0.845845 |
| eRrightStd | 0.113415 |
| eRrightStdnorm | 0.134085 |
| eRrightMedian | 0.865385 |
| eRrightQuartdelta | 0.167138 |
| eRrightQuartdeltanorm | 0.193137 |
| eRrightKurt | 2.23312 |
| eRrightTrenddiff | -0.068609 |
| eRleftMean | 0.381511 |
| eRleftStd | 0.184525 |
| eRleftStdnorm | 0.483668 |
| eRleftMedian | 0.367347 |
| eRleftQuartdelta | 0.186449 |
| eRleftQuartdeltanorm | 0.507554 |
| eRleftKurt | 3.4824 |
| eRleftTrenddiff | 0.113799 |
| lDurationMean | 1.07781 |
| lDurationStd | 0.251941 |
| lDurationStdnorm | 0.233752 |
| lDurationMedian | 1.1075 |
| lDurationQuartdelta | 0.4125 |
| lDurationQuartdeltanorm | 0.37246 |
| lDurationKurt | 2.30979 |
| lDurationTrenddiff | 0.115 |
| lDurationTrendratio | 1.11386 |
| lWidthMean | 4.16812 |
| lWidthStd | 0.960564 |
| lWidthStdnorm | 0.230455 |
| lWidthMedian | 4.0365 |
| lWidthQuartdelta | 1.4625 |
| lWidthQuartdeltanorm | 0.362319 |
| lWidthKurt | 3.26516 |
| lWidthTrenddiff | -7.10543e-15 |
| lWidthTrendratio | 1 |
| lHeightMean | 11.1077 |
| lHeightStd | 3.35194 |
| lHeightStdnorm | 0.301768 |
| lHeightMedian | 11.0565 |
| lHeightQuartdelta | 3.627 |
| lHeightQuartdeltanorm | 0.328042 |
| lHeightKurt | 2.6967 |
| lHeightTrenddiff | -0.936 |
| lHeightTrendratio | 0.917098 |
| lAspectMean | 0.40378 |
| lAspectStd | 0.13463 |
| lAspectStdnorm | 0.333425 |
| lAspectMedian | 0.376115 |
| lAspectQuartdelta | 0.183044 |
| lAspectQuartdeltanorm | 0.48667 |
| lAspectKurt | 2.52274 |
| lAspectTrenddiff | 0.0211865 |
| lAspectTrendratio | 1.05836 |
| lSlantMean | 0.0720485 |
| lSlantStd | 0.111513 |
| lSlantStdnorm | 1.54776 |
| lSlantMedian | 0.0553858 |
| lSlantQuartdelta | 0.164391 |
| lSlantQuartdeltanorm | 2.96811 |
| lSlantKurt | 2.91557 |
| lSlantTrenddiff | -0.035489 |
| lRtopMean | 0.627794 |
| lRtopStd | 0.17551 |
| lRtopStdnorm | 0.279566 |
| lRtopMedian | 0.62069 |
| lRtopQuartdelta | 0.190069 |
| lRtopQuartdeltanorm | 0.306222 |
| lRtopKurt | 2.57021 |
| lRtopTrenddiff | 0.000738916 |
| lRbotMean | 0.486791 |
| lRbotStd | 0.166745 |
| lRbotStdnorm | 0.342538 |
| lRbotMedian | 0.503284 |
| lRbotQuartdelta | 0.182732 |
| lRbotQuartdeltanorm | 0.363079 |
| lRbotKurt | 3.39236 |
| lRbotTrenddiff | 0.111691 |
| lRrightMean | 0.818043 |
| lRrightStd | 0.144965 |
| lRrightStdnorm | 0.177209 |
| lRrightMedian | 0.856631 |
| lRrightQuartdelta | 0.152406 |
| lRrightQuartdeltanorm | 0.177913 |
| lRrightKurt | 5.29384 |
| lRrightTrenddiff | 0.114476 |
| lRleftMean | 0.357326 |
| lRleftStd | 0.178048 |
| lRleftStdnorm | 0.498278 |
| lRleftMedian | 0.311326 |
| lRleftQuartdelta | 0.219599 |
| lRleftQuartdeltanorm | 0.705367 |
| lRleftKurt | 3.69348 |
| lRleftTrenddiff | 0.0572266 |
Elel Segment 1
Elel Segment 2
Elel Segment 3
Elel Segment 4
Elel Segment 5
Elel Segment 6
Elel Segment 7
Elel Segment 8
Elel Segment 9
Elel Segment 10
Elel Segment 11
Elel Segment 12
Elel Segment 13
Elel Segment 14
Elel Segment 15
Elel Segment 16
Elel Segment 17
Elel Segment 18
Elel Segment 19
Elel Segment 20
Elel Segment 21
Elel Segment 22
Elel Segment 23
Elel Segment 24
Elel Segment 25
Elel Segment 26
Elel Segment 27
Elel Segment 28
Elel Segment 29
Elel Segment 30
Elel Segment 31
Elel Segment 32
Elel Segment 33
Elel Segment 34
Elel Segment 35
Elel Segment 36
Elel Segment 37
Elel Segment 38
FITTS Short Modified
| meanTouchScore | 0.751812 |
| sumTouchScores | 7.51812 |
| meanMovementTime | 1.66389 |
| numTouches | 10 |
| undershootPercentage | 0 |
| overshootPercentage | 30 |
FITTS Long Modified
| meanTouchScore | 0.90319 |
| sumTouchScores | 9.93509 |
| meanMovementTime | 1.955 |
| numTouches | 11 |
| undershootPercentage | 9.09091 |
| overshootPercentage | 9.09091 |
ZigZag
| numZigzags | 5 |
| timePerZigzagMean | 55.816 |
| timePerZigzagCoV | 0.239054 |
| timePerZigzagSlope | -0.132292 |
| meanError | 1.60632 |
| tremorFreq | 6.05469 |
| tremorRelPower | 38.1575 |
| tremorGyroAmpMean | 0.082756 |
| tremorGyroAmpSlope | 0.00265735 |
| tremorGyroAmpCoV | 0.475371 |
| tremorCoordAmpMean | 0.0900456 |
| tremorCoordAmpSlope | 0.00162688 |
| tremorCoordAmpCoV | 0.403183 |
| tremorAccAmpMean | 0.0866274 |
| tremorAccAmpSlope | 0.00136764 |
| tremorAccAmpCoV | 0.381351 |
| tremorPcRelVar | 0.778438 |
| tremorPcX | -0.977079 |
| tremorPcY | 0.212879 |
ZigZag Segment 1
Duration 77.48 s, Accuracy Estimate 1.747 (lower is better)
ZigZag Segment 2
Duration 59.68 s, Accuracy Estimate 1.541 (lower is better)
ZigZag Segment 3
Duration 49.16 s, Accuracy Estimate 1.586 (lower is better)
ZigZag Segment 4
Duration 44.72 s, Accuracy Estimate 1.45 (lower is better)
ZigZag Segment 5
Duration 48.04 s, Accuracy Estimate 1.707 (lower is better)
ZigZag Offset
| numZigzags | 6 |
| timePerZigzagMean | 28.4533 |
| timePerZigzagCoV | 0.128549 |
| timePerZigzagSlope | -0.0623377 |
| zigzagHeightMean | 56.7396 |
| zigzagHeightCoV | 0.034052 |
| zigzagHeightSlope | 0.00573627 |
| meanError | 0.0504194 |
| tremorFreq | 6.44531 |
| tremorRelPower | 30.651 |
| tremorGyroAmpMean | 0.0480603 |
| tremorGyroAmpSlope | 0.000235173 |
| tremorGyroAmpCoV | 0.400118 |
| tremorCoordAmpMean | 0.0681655 |
| tremorCoordAmpSlope | 0.00221649 |
| tremorCoordAmpCoV | 0.325817 |
| tremorAccAmpMean | 0.0556986 |
| tremorAccAmpSlope | 0.00178728 |
| tremorAccAmpCoV | 0.32072 |
| tremorPcRelVar | 0.695675 |
| tremorPcX | -0.489684 |
| tremorPcY | -0.8719 |
ZigZag Offset Segment 1
Duration 33.48 s, Accuracy Estimate 0.046 (lower is better)
ZigZag Offset Segment 2
Duration 29.44 s, Accuracy Estimate 0.029 (lower is better)
ZigZag Offset Segment 3
Duration 29.04 s, Accuracy Estimate 0.035 (lower is better)
ZigZag Offset Segment 4
Duration 30.32 s, Accuracy Estimate 0.069 (lower is better)
ZigZag Offset Segment 5
Duration 24.92 s, Accuracy Estimate 0.054 (lower is better)
ZigZag Offset Segment 6
Duration 23.52 s, Accuracy Estimate 0.069 (lower is better)
Appendices
Misc
Currently a dumping ground for things that could be included or previous output style.
Note
Putting all the results out here but will not be in a final report.
| HiSpec | {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.86} |
| RanFor | {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.58} |
| BM_May22 | {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.6690386514909599} |
| BM_HC_Sep22 | {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.885877322892447} |
| BM_PD_Sep22 | {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4005964388142639} |
