Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC065
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-31 13:37
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl Madopar 1\2+1\4+1\4+1\2

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 24, 'TN': 19, 'TP': 18, 'FP': 11}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 29, 'TP': 1, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 12, 'TN': 9, 'TP': 30, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 18.3
timePerCircleCoV 0.336051
timePerCircleSlope -0.0883193
meanError 2.16381
tremorFreq 6.64062
tremorRelPower 29.6094
tremorGyroAmpMean 0.0457199
tremorGyroAmpSlope 0.00226941
tremorGyroAmpCoV 0.443635
tremorCoordAmpMean 0.0722201
tremorCoordAmpSlope 0.00213313
tremorCoordAmpCoV 0.46586
tremorAccAmpMean 0.0626467
tremorAccAmpSlope 0.00182368
tremorAccAmpCoV 0.468561
tremorPcRelVar 0.835378
tremorPcX -0.722199
tremorPcY 0.691685

Circle Segment 1

Duration 33.36 s, Accuracy Estimate 3.552 (lower is better)

Circle Segment 2

Duration 23.36 s, Accuracy Estimate 2.145 (lower is better)

Circle Segment 3

Duration 20.68 s, Accuracy Estimate 1.786 (lower is better)

Circle Segment 4

Duration 17.72 s, Accuracy Estimate 1.727 (lower is better)

Circle Segment 5

Duration 15.28 s, Accuracy Estimate 1.702 (lower is better)

Circle Segment 6

Duration 14.0 s, Accuracy Estimate 1.698 (lower is better)

Circle Segment 7

Duration 13.76 s, Accuracy Estimate 2.046 (lower is better)

Circle Segment 8

Duration 15.0 s, Accuracy Estimate 1.712 (lower is better)

Circle Segment 9

Duration 14.96 s, Accuracy Estimate 1.868 (lower is better)

Circle Segment 10

Duration 14.88 s, Accuracy Estimate 3.402 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 35.465
timePerSpiralCoV 0.289426
timePerSpiralSlope -0.0948353
meanError 2.51141
tremorFreq 6.73828
tremorRelPower 42.0717
tremorGyroAmpMean 0.0705067
tremorGyroAmpSlope 0.000530822
tremorGyroAmpCoV 0.487608
tremorCoordAmpMean 0.107009
tremorCoordAmpSlope 0.00156939
tremorCoordAmpCoV 0.462708
tremorAccAmpMean 0.086356
tremorAccAmpSlope 0.00052239
tremorAccAmpCoV 0.451706
tremorPcRelVar 0.793247
tremorPcX 0.897508
tremorPcY 0.440998

Spiral Segment 1

Duration 59.04 s, Accuracy Estimate 2.068 (lower is better)

Spiral Segment 2

Duration 38.8 s, Accuracy Estimate 2.562 (lower is better)

Spiral Segment 3

Duration 35.88 s, Accuracy Estimate 2.338 (lower is better)

Spiral Segment 4

Duration 32.52 s, Accuracy Estimate 2.9 (lower is better)

Spiral Segment 5

Duration 29.48 s, Accuracy Estimate 2.572 (lower is better)

Spiral Segment 6

Duration 31.8 s, Accuracy Estimate 2.614 (lower is better)

Spiral Segment 7

Duration 26.68 s, Accuracy Estimate 2.552 (lower is better)

Spiral Segment 8

Duration 29.52 s, Accuracy Estimate 2.486 (lower is better)

Elel

eDurationMean 0.813718
eDurationStd 0.217485
eDurationStdnorm 0.267273
eDurationMedian 0.745
eDurationQuartdelta 0.27
eDurationQuartdeltanorm 0.362416
eDurationKurt 3.56325
eDurationTrenddiff 0.05
eDurationTrendratio 1.06993
eWidthMean 3.339
eWidthStd 0.839781
eWidthStdnorm 0.251507
eWidthMedian 3.393
eWidthQuartdelta 1.02375
eWidthQuartdeltanorm 0.301724
eWidthKurt 4.77911
eWidthTrenddiff -0.234
eWidthTrendratio 0.931034
eHeightMean 7.185
eHeightStd 2.50459
eHeightStdnorm 0.348586
eHeightMedian 6.435
eHeightQuartdelta 2.5155
eHeightQuartdeltanorm 0.390909
eHeightKurt 3.19967
eHeightTrenddiff -0.351
eHeightTrendratio 0.946429
eAspectMean 0.489855
eAspectStd 0.126155
eAspectStdnorm 0.257536
eAspectMedian 0.469388
eAspectQuartdelta 0.197565
eAspectQuartdeltanorm 0.420899
eAspectKurt 2.56522
eAspectTrenddiff 0.0293904
eAspectTrendratio 1.06645
eSlantMean 0.00654564
eSlantStd 0.223726
eSlantStdnorm 34.1794
eSlantMedian -0.0153846
eSlantQuartdelta 0.225178
eSlantQuartdeltanorm -14.6366
eSlantKurt 4.39855
eSlantTrenddiff -0.0408163
eRtopMean 0.713266
eRtopStd 0.159096
eRtopStdnorm 0.223053
eRtopMedian 0.722222
eRtopQuartdelta 0.267355
eRtopQuartdeltanorm 0.370184
eRtopKurt 2.05549
eRtopTrenddiff -0.0316206
eRbotMean 0.720549
eRbotStd 0.357195
eRbotStdnorm 0.495727
eRbotMedian 0.705882
eRbotQuartdelta 0.484375
eRbotQuartdeltanorm 0.686198
eRbotKurt 2.96749
eRbotTrenddiff 0.191667
eRrightMean 0.845845
eRrightStd 0.113415
eRrightStdnorm 0.134085
eRrightMedian 0.865385
eRrightQuartdelta 0.167138
eRrightQuartdeltanorm 0.193137
eRrightKurt 2.23312
eRrightTrenddiff -0.068609
eRleftMean 0.381511
eRleftStd 0.184525
eRleftStdnorm 0.483668
eRleftMedian 0.367347
eRleftQuartdelta 0.186449
eRleftQuartdeltanorm 0.507554
eRleftKurt 3.4824
eRleftTrenddiff 0.113799
lDurationMean 1.07781
lDurationStd 0.251941
lDurationStdnorm 0.233752
lDurationMedian 1.1075
lDurationQuartdelta 0.4125
lDurationQuartdeltanorm 0.37246
lDurationKurt 2.30979
lDurationTrenddiff 0.115
lDurationTrendratio 1.11386
lWidthMean 4.16812
lWidthStd 0.960564
lWidthStdnorm 0.230455
lWidthMedian 4.0365
lWidthQuartdelta 1.4625
lWidthQuartdeltanorm 0.362319
lWidthKurt 3.26516
lWidthTrenddiff -7.10543e-15
lWidthTrendratio 1
lHeightMean 11.1077
lHeightStd 3.35194
lHeightStdnorm 0.301768
lHeightMedian 11.0565
lHeightQuartdelta 3.627
lHeightQuartdeltanorm 0.328042
lHeightKurt 2.6967
lHeightTrenddiff -0.936
lHeightTrendratio 0.917098
lAspectMean 0.40378
lAspectStd 0.13463
lAspectStdnorm 0.333425
lAspectMedian 0.376115
lAspectQuartdelta 0.183044
lAspectQuartdeltanorm 0.48667
lAspectKurt 2.52274
lAspectTrenddiff 0.0211865
lAspectTrendratio 1.05836
lSlantMean 0.0720485
lSlantStd 0.111513
lSlantStdnorm 1.54776
lSlantMedian 0.0553858
lSlantQuartdelta 0.164391
lSlantQuartdeltanorm 2.96811
lSlantKurt 2.91557
lSlantTrenddiff -0.035489
lRtopMean 0.627794
lRtopStd 0.17551
lRtopStdnorm 0.279566
lRtopMedian 0.62069
lRtopQuartdelta 0.190069
lRtopQuartdeltanorm 0.306222
lRtopKurt 2.57021
lRtopTrenddiff 0.000738916
lRbotMean 0.486791
lRbotStd 0.166745
lRbotStdnorm 0.342538
lRbotMedian 0.503284
lRbotQuartdelta 0.182732
lRbotQuartdeltanorm 0.363079
lRbotKurt 3.39236
lRbotTrenddiff 0.111691
lRrightMean 0.818043
lRrightStd 0.144965
lRrightStdnorm 0.177209
lRrightMedian 0.856631
lRrightQuartdelta 0.152406
lRrightQuartdeltanorm 0.177913
lRrightKurt 5.29384
lRrightTrenddiff 0.114476
lRleftMean 0.357326
lRleftStd 0.178048
lRleftStdnorm 0.498278
lRleftMedian 0.311326
lRleftQuartdelta 0.219599
lRleftQuartdeltanorm 0.705367
lRleftKurt 3.69348
lRleftTrenddiff 0.0572266

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

Elel Segment 16

Elel Segment 17

Elel Segment 18

Elel Segment 19

Elel Segment 20

Elel Segment 21

Elel Segment 22

Elel Segment 23

Elel Segment 24

Elel Segment 25

Elel Segment 26

Elel Segment 27

Elel Segment 28

Elel Segment 29

Elel Segment 30

Elel Segment 31

Elel Segment 32

Elel Segment 33

Elel Segment 34

Elel Segment 35

Elel Segment 36

Elel Segment 37

Elel Segment 38

FITTS Short Modified

meanTouchScore 0.751812
sumTouchScores 7.51812
meanMovementTime 1.66389
numTouches 10
undershootPercentage 0
overshootPercentage 30

FITTS Long Modified

meanTouchScore 0.90319
sumTouchScores 9.93509
meanMovementTime 1.955
numTouches 11
undershootPercentage 9.09091
overshootPercentage 9.09091

ZigZag

numZigzags 5
timePerZigzagMean 55.816
timePerZigzagCoV 0.239054
timePerZigzagSlope -0.132292
meanError 1.60632
tremorFreq 6.05469
tremorRelPower 38.1575
tremorGyroAmpMean 0.082756
tremorGyroAmpSlope 0.00265735
tremorGyroAmpCoV 0.475371
tremorCoordAmpMean 0.0900456
tremorCoordAmpSlope 0.00162688
tremorCoordAmpCoV 0.403183
tremorAccAmpMean 0.0866274
tremorAccAmpSlope 0.00136764
tremorAccAmpCoV 0.381351
tremorPcRelVar 0.778438
tremorPcX -0.977079
tremorPcY 0.212879

ZigZag Segment 1

Duration 77.48 s, Accuracy Estimate 1.747 (lower is better)

ZigZag Segment 2

Duration 59.68 s, Accuracy Estimate 1.541 (lower is better)

ZigZag Segment 3

Duration 49.16 s, Accuracy Estimate 1.586 (lower is better)

ZigZag Segment 4

Duration 44.72 s, Accuracy Estimate 1.45 (lower is better)

ZigZag Segment 5

Duration 48.04 s, Accuracy Estimate 1.707 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 28.4533
timePerZigzagCoV 0.128549
timePerZigzagSlope -0.0623377
zigzagHeightMean 56.7396
zigzagHeightCoV 0.034052
zigzagHeightSlope 0.00573627
meanError 0.0504194
tremorFreq 6.44531
tremorRelPower 30.651
tremorGyroAmpMean 0.0480603
tremorGyroAmpSlope 0.000235173
tremorGyroAmpCoV 0.400118
tremorCoordAmpMean 0.0681655
tremorCoordAmpSlope 0.00221649
tremorCoordAmpCoV 0.325817
tremorAccAmpMean 0.0556986
tremorAccAmpSlope 0.00178728
tremorAccAmpCoV 0.32072
tremorPcRelVar 0.695675
tremorPcX -0.489684
tremorPcY -0.8719

ZigZag Offset Segment 1

Duration 33.48 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 2

Duration 29.44 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 3

Duration 29.04 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 4

Duration 30.32 s, Accuracy Estimate 0.069 (lower is better)

ZigZag Offset Segment 5

Duration 24.92 s, Accuracy Estimate 0.054 (lower is better)

ZigZag Offset Segment 6

Duration 23.52 s, Accuracy Estimate 0.069 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.86}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.6690386514909599}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.885877322892447}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4005964388142639}